Biotechnology
BIOT 5850: Higher-Order Structure Analytics
Lecture - 3 credits
ND
EI
IC
FQ
SI
AD
DD
ER
WF
WD
WI
EX
CE
- Offers a comprehensive look at various aspects of higher- order protein structures in biotherapeutics and their implications on biological drug design.
- Focuses heavily on protein aggregation, a type of HOS, and analysis of those aggregates including functional implications.
- Topics include a review of protein structure, protein aggregation, functional aspects, and techniques to reduce HOS using protein expression and purification strategies, protein folding in disease, macromolecular crystallography, nuclear magnetic resonance, analytical ultracentrifugation, circular dichroism, light scattering, electron spin labelling, cryo-EM, WAXS, and HDX-MS.
- Highlights experimental design and application to the biotechnology industry in identifying and reducing HOS.
Offers a comprehensive look at various aspects of higher- order protein structures in biotherapeutics and their implications on biological drug design. Show more.